POLR2E

Across TCGA patient cohorts, POLR2E mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2E-associated genes across cancer lineages are Adipocytes, Monocytes, and CLP. Each is linked with POLR2E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2E-to-partner and partner-to-POLR2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adipocytes grouped by POLR2E-low versus POLR2E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2E→partner) and Y-score (partner→POLR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Adipocytes →	+0.047	+3.244	<.001	.020	3	2
COAD	Monocytes →	+0.048	+5.734	<.001	.027	3	1
SKCM	CLP →	+0.094	+3.019	.036	.019	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Adipocytes by POLR2E expression — UCEC

Explore this box plot interactively →