POLR2E

Across TCGA cell cohorts, POLR2E RNA expression is significantly associated with the go_rna of many other GO terms, with 4,533 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLR2E-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and Energy coupled proton transmembrane transport, against electrochemical gradient. Each is linked with POLR2E in more than 17 cancer types. Because this analysis shows association rather than direction, both POLR2E-to-partner and partner-to-POLR2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by POLR2E-low versus POLR2E-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2E→partner) and Y-score (partner→POLR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.212	+0.705	<.001	<.001	3	18
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.234	+0.757	.001	<.001	3	17
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.116	+0.593	<.001	.005	3	16
BONE	Electron transport coupled proton transport →	+0.116	+0.593	<.001	.005	3	16
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.158	+0.551	<.001	<.001	3	15
BONE	DNA replication-dependent chromatin assembly →	+0.191	+0.750	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,533 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by POLR2E expression — BONE

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