POLR2E

Across TCGA cell cohorts, POLR2E mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR2E-associated genes across cancer lineages are GHRHR, ODF1, and MAGEC3. Each is linked with POLR2E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2E-to-partner and partner-to-POLR2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by POLR2E-low versus POLR2E-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2E→partner) and Y-score (partner→POLR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.370	+3.705	<.001	.007	3	2
BLOOD_Leukemia	ODF1 →	+0.066	+3.944	.001	.006	3	1
BLOOD_Leukemia	MAGEC3 →	+0.213	+3.855	.006	.007	3	1
BLOOD_Leukemia	TEX48 →	+0.037	+4.060	<.001	.003	3	1
BLOOD_Leukemia	CCDC166 →	+0.033	+3.855	<.001	.007	3	1
BLOOD_Leukemia	OR6J1 →	+0.046	+4.234	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GHRHR by POLR2E expression — BLOOD_Leukemia

Explore this box plot interactively →