POLR2C

Across TCGA pan-cancer cohorts, POLR2C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLR2C data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2C expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where POLR2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.885	0.986	<.001	46	view →
LUAD	OS	Median	III,IV	0.823	0.289	<.001	33	view →
GBM	OS	Tertile	All	0.569	0.335	.009	12	view →
PDAC	DFS	Quartile	All	0.524	0.266	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLR2C–HNSC (DFS)

Open the HNSC breakdown →