POLR2B

Across TCGA patient cohorts, POLR2B protein abundance is significantly associated with the RNA expression of many other genes, with 15,773 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR2B-associated genes across cancer lineages are TMEM97, POLR1C, and RMI2. Each is linked with POLR2B in more than 6 cancer types. Because this analysis shows association rather than direction, both POLR2B-to-partner and partner-to-POLR2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2B versus TMEM97 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2B→partner) and Y-score (partner→POLR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM97 →	+1.013	+0.158	<.001	<.001	3	7
HNSC	POLR1C →	+0.664	+0.198	<.001	<.001	3	7
LSCC	RMI2 →	+0.832	+0.235	<.001	<.001	3	7
HNSC	PRR3 →	+0.589	+0.134	<.001	<.001	3	7
OV	MKS1 →	+0.546	+0.129	<.001	.003	3	6
OV	TGIF2 →	+0.612	+0.149	.002	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,773 associations by consensus.

POLR2B vs TMEM97 — HNSC

Explore this scatter interactively →