POLR2A

Across TCGA pan-cancer cohorts, POLR2A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated POLR2A data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher POLR2A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR2A expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, LIHC, and PCPG are the cancer types where POLR2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.948	0.826	.019	22	view →
LIHC	OS	Median	All	0.214	0.778	<.001	21	view →
PCPG	DFS	Median	All	0.070	0.936	<.001	6	view →
KIRC	DFS	Median	All	0.198	0.796	.005	6	view →
LGG	OS	Median	All	0.214	0.889	<.001	6	view →
BLCA	OS	Median	II,III,IV	0.888	0.407	.018	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	6	view →
SCLC	DFS	Median	All	1.000	0.451	.008	5	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

POLR2A–UCEC (DFS)

Open the UCEC breakdown →