POLR2A

Across TCGA patient cohorts, POLR2A RNA expression is significantly associated with the protein abundance of many other proteins, with 9,990 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POLR2A-associated proteins across cancer lineages are FXR2, PTK2_Y576, and MYG1. Each is linked with POLR2A in more than 3 cancer types. Because this analysis shows association rather than direction, both POLR2A-to-partner and partner-to-POLR2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2A versus FXR2 in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2A→partner) and Y-score (partner→POLR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FXR2 →	+0.242	+0.953	<.001	<.001	3	4
LUAD	PTK2_Y576 →	-0.630	-0.498	.003	<.001	3	4
LSCC	MYG1 →	+0.245	+0.540	<.001	.002	3	3
LUAD	GMNN →	+0.732	+0.559	.005	.002	3	3
PDAC	SLC25A13 →	-0.438	-0.319	<.001	.001	3	3
LSCC	DOCK10_S1451 →	-0.576	-0.431	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,990 associations by consensus.

POLR2A vs FXR2 — HNSC

Explore this scatter interactively →