POLR2A

Across TCGA patient cohorts, POLR2A protein abundance is significantly associated with the RNA expression of many other genes, with 16,272 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR2A-associated genes across cancer lineages are BLMH, CLK2, and RFC5. Each is linked with POLR2A in more than 6 cancer types. Because this analysis shows association rather than direction, both POLR2A-to-partner and partner-to-POLR2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2A versus BLMH in COAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2A→partner) and Y-score (partner→POLR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BLMH →	+0.718	+0.179	<.001	<.001	3	7
HNSC	CLK2 →	+0.459	+0.145	.007	<.001	3	7
LSCC	RFC5 →	+0.660	+0.154	<.001	<.001	3	7
UCEC	SNRPE →	+0.809	+0.092	<.001	.001	3	7
GBM	LIN9 →	+0.798	+0.289	<.001	<.001	3	7
HNSC	RBM8A →	+0.598	+0.124	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,272 associations by consensus.

POLR2A vs BLMH — COAD

Explore this scatter interactively →