POLR2A

Across TCGA cell cohorts, POLR2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,671 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR2A-associated GO terms across cancer lineages are RNA export from nucleus, mRNA transport, and mRNA alternative polyadenylation. Each is linked with POLR2A in more than 17 cancer types. Because this analysis shows association rather than direction, both POLR2A-to-partner and partner-to-POLR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by POLR2A-low versus POLR2A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2A→partner) and Y-score (partner→POLR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNA export from nucleus →	+0.159	+1.493	<.001	<.001	3	18
OESOPHAGUS	mRNA transport →	+0.166	+1.513	.001	<.001	3	18
SOFT_TISSUE	mRNA alternative polyadenylation →	+0.107	+1.454	<.001	<.001	3	17
OESOPHAGUS	Regulation of DNA-templated transcription initiation →	+0.077	+0.998	.003	.005	3	17
OESOPHAGUS	RNA-templated transcription →	+0.221	+1.567	<.001	<.001	3	17
OESOPHAGUS	Nucleic acid transport →	+0.094	+0.999	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,671 associations by consensus.

RNA export from nucleus by POLR2A expression — SOFT_TISSUE

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