POLR1H

Across TCGA patient cohorts, POLR1H mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1H-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and JNK2. Each is linked with POLR1H in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1H-to-partner and partner-to-POLR1H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by POLR1H-low versus POLR1H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1H→partner) and Y-score (partner→POLR1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.280	+3.584	.025	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.170	-3.160	.004	.019	3	1
UCEC	JNK2 →	+0.319	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.366	+3.598	.001	.001	3	1
UCEC	Rab11 →	-0.145	-2.459	.038	.020	3	1
UCEC	Rictor_pT1135 →	-0.132	-3.169	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FoxM1 by POLR1H expression — UCEC

Explore this box plot interactively →