POLR1H

Across TCGA pan-cancer cohorts, POLR1H RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated POLR1H data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher POLR1H RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR1H expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

BLCA, KIRP, and LIHC are the cancer types where POLR1H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	II,III,IV	0.393	0.280	<.001	70	view →
KIRP	OS	Tertile	II,III,IV	0.605	0.946	<.001	65	view →
LIHC	OS	Quartile	III,IV	0.454	0.778	.002	45	view →
KICH	OS	Median	All	0.678	1.000	.003	33	view →
ACC	DFS	Tertile	All	0.185	0.731	<.001	30	view →
HNSC	DFS	Median	All	0.550	0.688	.001	25	view →
UCS	DFS	Tertile	IV	0.403	0.942	.024	24	view →
LUAD	DFS	Median	All	0.486	0.170	.003	24	view →
THYM	OS	Median	All	0.965	0.781	.009	17	view →
SARC	OS	Quartile	All	0.638	0.876	<.001	16	view →
COAD	DFS	Quartile	All	0.708	0.832	.009	15	view →
TGCT	DFS	Tertile	All	0.735	0.927	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

POLR1H–BLCA (DFS)

Open the BLCA breakdown →