POLR1G

Across TCGA pan-cancer cohorts, POLR1G mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLR1G data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR1G mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR1G expression acts as an unfavorable survival marker.

HNSC, PDAC, and CCRCC are the cancer types where POLR1G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.533	0.827	.004	45	view →
PDAC	OS	Median	All	0.272	0.454	.004	31	view →
CCRCC	OS	Quartile	III,IV	0.431	0.841	.017	15	view →
LUAD	DFS	Median	All	0.655	0.956	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLR1G–HNSC (DFS)

Open the HNSC breakdown →