POLR1G

Across TCGA pan-cancer cohorts, POLR1G RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of POLR1G’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POLR1G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR1G is over-expressed in tumor.

COAD, HNSC, and BLCA are the cancer types where POLR1G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR1G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.589	<.001	12	view →
HNSC	Male	All	+1.151	<.001	12	view →
BLCA	Male	III,IV	+1.450	<.001	11	view →
KIRC	Male	All	+0.685	<.001	11	view →
THCA	Male	IV	+0.363	<.001	11	view →
STAD	Female	All	+1.467	<.001	9	view →
LIHC	Male	II,III,IV	+1.282	<.001	9	view →
LUAD	Male	III,IV	+1.221	<.001	9	view →
KIRP	All	II,III,IV	+0.832	<.001	9	view →
LUSC	Male	III,IV	+1.860	<.001	8	view →
UCEC	All	III,IV	+1.016	<.001	8	view →
BRCA	All	III,IV	+0.934	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

POLR1G–COAD

Open the COAD breakdown →