POLR1G

Across TCGA cell cohorts, POLR1G mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR1G-associated genes across cancer lineages are MRGPRX4, ASCL3, and CCDC195. Each is linked with POLR1G in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1G-to-partner and partner-to-POLR1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRX4 grouped by POLR1G-low versus POLR1G-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1G→partner) and Y-score (partner→POLR1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MRGPRX4 →	+0.012	+4.922	.003	.009	3	1
LARGE_INTESTINE	ASCL3 →	+0.191	+3.726	<.001	.004	3	1
LARGE_INTESTINE	CCDC195 →	+0.054	+3.882	<.001	.001	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MRGPRX4 by POLR1G expression — BLOOD_Leukemia

Explore this box plot interactively →