POLR1F

Across TCGA pan-cancer cohorts, POLR1F Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLR1F data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher POLR1F Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POLR1F expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, DLBC, and BRCA are the cancer types where POLR1F Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.806	.002	24	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
BRCA	DFS	Median	All	0.075	0.903	<.001	12	view →
UCEC	DFS	Median	All	0.959	0.620	.018	8	view →
LUAD	OS	Median	II,III,IV	0.245	0.749	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POLR1F–COAD (OS)

Open the COAD breakdown →