POLR1F

Across TCGA pan-cancer cohorts, POLR1F mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR1F data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLR1F mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR1F expression acts as an unfavorable survival marker.

LUAD, PDAC, and UCEC are the cancer types where POLR1F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.409	0.941	.010	10	view →
PDAC	OS	Median	III,IV	0.304	0.525	.025	9	view →
UCEC	OS	Tertile	III,IV	0.377	1.000	.013	8	view →
LSCC	OS	Quartile	III,IV	0.533	0.970	.042	5	view →
HNSC	DFS	Tertile	IV	0.485	0.744	.011	4	view →
CCRCC	DFS	Median	II,III,IV	0.824	0.962	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR1F–LUAD (DFS)

Open the LUAD breakdown →