POLR1F

Across TCGA patient cohorts, POLR1F mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1F-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and A-Raf_pS299. Each is linked with POLR1F in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1F-to-partner and partner-to-POLR1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by POLR1F-low versus POLR1F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1F→partner) and Y-score (partner→POLR1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-2.584	.008	.010	3	1
UCEC	eIF4G →	+0.334	+2.584	.007	.010	3	1
UCEC	A-Raf_pS299 →	-0.160	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.194	+3.169	.012	.018	3	1
UCEC	FoxM1 →	+0.208	+1.906	.045	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.117	-1.797	.020	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by POLR1F expression — UCEC

Explore this box plot interactively →