POLR1E

Across TCGA pan-cancer cohorts, POLR1E mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated POLR1E data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POLR1E mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR1E expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where POLR1E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.429	0.792	.004	52	view →
HNSC	DFS	Median	All	0.693	0.860	.002	34	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	19	view →
GBM	OS	Quartile	All	0.754	0.524	.007	8	view →
PDAC	DFS	Median	II,III,IV	0.309	0.508	.014	7	view →
UCEC	DFS	Quartile	All	0.822	0.979	.013	6	view →
LSCC	DFS	Median	II,III,IV	0.796	0.536	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

POLR1E–CCRCC (DFS)

Open the CCRCC breakdown →