POLR1E

Across TCGA patient cohorts, POLR1E protein abundance is significantly associated with the protein abundance of many other proteins, with 26,618 significant associations in total. GBM shows the largest number of these associations.

The most reproducible POLR1E-associated proteins across cancer lineages are CPSF3, CSE1L, and DDX21. Each is linked with POLR1E in more than 9 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR1E versus CPSF3 in UCEC, with a Pearson correlation of 0.53.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CPSF3 →	+0.253	+0.397	<.001	<.001	3	10
BRCA	CSE1L →	+0.361	+0.378	<.001	<.001	3	10
BRCA	DDX21 →	+0.643	+0.470	<.001	<.001	3	10
BRCA	DDX56 →	+0.395	+0.511	<.001	<.001	3	10
OV	DHX9 →	+0.373	+1.110	<.001	<.001	3	10
GBM	EFTUD2 →	+0.219	+0.321	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,618 associations by consensus.

POLR1E vs CPSF3 — UCEC

Explore this scatter interactively →