POLR1E

Across TCGA patient cohorts, POLR1E mutation is significantly associated with the RNA expression of many other genes, with 2,407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1E-associated genes across cancer lineages are FXYD6P1, IFNA21, and BTBD10. Each is linked with POLR1E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXYD6P1 grouped by POLR1E-low versus POLR1E-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FXYD6P1 →	+0.146	+3.801	<.001	.007	3	1
COAD	IFNA21 →	+0.089	+4.910	.003	.002	3	1
UCEC	BTBD10 →	+0.471	+3.617	.002	.001	3	1
UCEC	LIN7C →	+0.592	+3.743	.001	<.001	3	1
UCEC	PGAP2 →	+0.389	+2.673	.003	<.001	3	1
UCEC	PTPRJ →	+0.617	+3.343	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,407 associations by consensus.

FXYD6P1 by POLR1E expression — SKCM

Explore this box plot interactively →