POLR1E

Across TCGA patient cohorts, POLR1E mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1E-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and A-Raf_pS299. Each is linked with POLR1E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by POLR1E-low versus POLR1E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-2.973	.021	.035	3	1
UCEC	eIF4G →	+0.297	+2.999	.024	.035	3	1
UCEC	A-Raf_pS299 →	-0.118	-2.321	.019	.034	3	1
UCEC	JNK2 →	+0.244	+2.834	.003	.034	3	1
UCEC	Ku80 →	+0.232	+1.713	.020	.027	3	1
UCEC	mTOR_pS2448 →	-0.130	-1.700	.040	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by POLR1E expression — UCEC

Explore this box plot interactively →