POLR1E

Across TCGA cell cohorts, POLR1E RNA expression is significantly associated with the go_rna of many other GO terms, with 3,774 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible POLR1E-associated GO terms across cancer lineages are tRNA surveillance, Nucleolar large rRNA transcription by RNA polymerase I, and Transcription initiation at RNA polymerase I promoter. Each is linked with POLR1E in more than 16 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA surveillance grouped by POLR1E-low versus POLR1E-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	tRNA surveillance →	+0.112	+1.043	.001	.001	3	17
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.163	+0.579	<.001	.004	3	16
URINARY_TRACT	Transcription initiation at RNA polymerase I promoter →	+0.116	+1.495	.002	<.001	3	16
URINARY_TRACT	Transcription elongation by RNA polymerase I →	+0.148	+1.155	<.001	.003	3	15
BONE	Nuclear polyadenylation-dependent rRNA catabolic process →	+0.154	+0.758	<.001	<.001	3	15
BONE	TRAMP-dependent tRNA surveillance pathway →	+0.154	+0.758	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,774 associations by consensus.

tRNA surveillance by POLR1E expression — PANCREAS

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