POLR1E

Across TCGA cell cohorts, POLR1E mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR1E-associated genes across cancer lineages are PNPLA5, OR52B2, and GALR3. Each is linked with POLR1E in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA5 grouped by POLR1E-low versus POLR1E-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PNPLA5 →	+0.016	+4.409	.009	.005	3	1
BLOOD_Lymphoma	OR52B2 →	+0.031	+4.714	<.001	.002	3	1
LARGE_INTESTINE	GALR3 →	+0.105	+3.865	<.001	.001	3	1
LARGE_INTESTINE	TKTL2 →	+0.037	+3.187	.002	.006	3	1
LARGE_INTESTINE	GRM1 →	+0.040	+4.334	<.001	<.001	3	1
LARGE_INTESTINE	FREM3 →	+0.105	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PNPLA5 by POLR1E expression — BLOOD_Leukemia

Explore this box plot interactively →