Across TCGA pan-cancer cohorts, POLR1D Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POLR1D data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher POLR1D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POLR1D expression acts as an unfavorable survival marker.

BLCA and SARC are the cancer types where POLR1D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.069	0.688	<.001	18	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: POLR1D tumor-vs-normal RNA expression · all POLR1D data types