Across TCGA pan-cancer cohorts, POLR1D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLR1D data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POLR1D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR1D expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where POLR1D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.858	0.971	.006	27	view →
HNSC	OS	Quartile	All	0.702	0.923	<.001	26	view →
LSCC	DFS	Median	II,III,IV	0.822	0.548	.024	10	view →
GBM	DFS	Tertile	All	0.520	0.260	.017	9	view →
LUAD	DFS	Quartile	II,III,IV	0.259	1.000	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: POLR1D tumor-vs-normal RNA expression · all POLR1D data types