POLR1B

Across TCGA cell cohorts, POLR1B mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR1B-associated genes across cancer lineages are OR2C1, RAX2, and OR52K1. Each is linked with POLR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1B-to-partner and partner-to-POLR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2C1 grouped by POLR1B-low versus POLR1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1B→partner) and Y-score (partner→POLR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2C1 →	+0.107	+3.578	.001	.006	3	1
LARGE_INTESTINE	RAX2 →	+0.081	+4.518	<.001	<.001	3	1
LARGE_INTESTINE	OR52K1 →	+0.012	+3.632	<.001	.003	3	1
BREAST	IL17F →	+0.043	+3.415	<.001	.004	3	1
BREAST	VCY1B →	+1.066	+3.836	.002	.001	3	1
BREAST	SPZ1 →	+0.016	+3.378	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR2C1 by POLR1B expression — LARGE_INTESTINE

Explore this box plot interactively →