POLR1A

Across TCGA pan-cancer cohorts, POLR1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLR1A data layer compared with 26 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher POLR1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR1A expression acts as an unfavorable survival marker.

PDAC, CCRCC, and HNSC are the cancer types where POLR1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.644	0.857	<.001	36	view →
CCRCC	OS	Median	II,III,IV	0.702	0.939	.011	35	view →
HNSC	DFS	Median	III,IV	0.689	0.881	.008	13	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLR1A–PDAC (DFS)

Open the PDAC breakdown →