POLR1A

Across TCGA pan-cancer cohorts, POLR1A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of POLR1A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POLR1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR1A is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, HNSC, and STAD are the cancer types where POLR1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.080	<.001	12	view →
HNSC	Male	All	+1.054	<.001	11	view →
STAD	Male	II,III,IV	+1.509	<.001	10	view →
LIHC	Female	II,III,IV	+1.599	<.001	9	view →
LUAD	All	III,IV	+0.840	<.001	9	view →
LUSC	Male	II,III,IV	+1.164	<.001	8	view →
BLCA	All	All	+0.587	<.001	8	view →
KIRP	Female	All	+0.672	.003	6	view →
BRCA	All	II,III,IV	+0.439	<.001	6	view →
CHOL	Male	All	+2.420	<.001	5	view →
THCA	Male	II,III,IV	−0.507	.015	5	view →
READ	All	All	+1.011	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

POLR1A–COAD

Open the COAD breakdown →