POLR1A

Across TCGA patient cohorts, POLR1A RNA expression is significantly associated with the protein abundance of many other proteins, with 17,708 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR1A-associated proteins across cancer lineages are ADNP, MSH6, and NONO. Each is linked with POLR1A in more than 6 cancer types. Because this analysis shows association rather than direction, both POLR1A-to-partner and partner-to-POLR1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR1A versus ADNP in HNSC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1A→partner) and Y-score (partner→POLR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADNP →	+0.385	+0.745	<.001	<.001	3	7
LSCC	MSH6 →	+0.671	+0.640	<.001	<.001	3	7
UCEC	NONO →	+0.245	+0.719	<.001	<.001	3	7
LSCC	PUS7 →	+0.539	+0.623	<.001	<.001	3	6
LSCC	RBM19 →	+0.399	+0.605	<.001	<.001	3	6
LSCC	RCL1 →	+0.276	+0.580	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,708 associations by consensus.

POLR1A vs ADNP — HNSC

Explore this scatter interactively →