POLR1A

Across TCGA patient cohorts, POLR1A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1A-associated genes across cancer lineages are ATM, ER-alpha_pS118, and MEK1. Each is linked with POLR1A in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR1A-to-partner and partner-to-POLR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by POLR1A-low versus POLR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1A→partner) and Y-score (partner→POLR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.474	-1.912	<.001	.004	3	3
UCEC	ER-alpha_pS118 →	+0.261	+1.920	.010	.008	3	3
UCEC	MEK1 →	+0.251	+1.999	.015	.008	3	3
UCEC	p62 Lck ligand →	+0.275	+2.009	.002	.001	3	3
UCEC	VHL →	-0.681	-1.523	<.001	.006	3	3
UCEC	c-Met_pY1235 →	+0.065	+1.784	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by POLR1A expression — UCEC

Explore this box plot interactively →