POLR1A

Across TCGA cell cohorts, POLR1A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,935 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLR1A-associated GO terms across cancer lineages are rRNA transcription, DNA-templated transcription elongation, and Regulation of transcription by RNA polymerase I. Each is linked with POLR1A in more than 19 cancer types. Because this analysis shows association rather than direction, both POLR1A-to-partner and partner-to-POLR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA transcription grouped by POLR1A-low versus POLR1A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1A→partner) and Y-score (partner→POLR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA transcription →	+0.152	+1.361	<.001	<.001	3	20
OVARY	DNA-templated transcription elongation →	+0.102	+1.130	<.001	<.001	3	18
BONE	Regulation of transcription by RNA polymerase I →	+0.167	+1.070	<.001	.007	3	18
BREAST	Transcription by RNA polymerase I →	+0.119	+0.956	<.001	<.001	3	18
OESOPHAGUS	Transcription initiation at RNA polymerase I promoter →	+0.139	+1.018	.003	.003	2	19
OESOPHAGUS	Nucleolar large rRNA transcription by RNA polymerase I →	+0.163	+1.218	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,935 associations by consensus.

rRNA transcription by POLR1A expression — BONE

Explore this box plot interactively →