POLR1A

Across TCGA cell cohorts, POLR1A mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR1A-associated genes across cancer lineages are B3GALT1, RAB19, and GPR3. Each is linked with POLR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1A-to-partner and partner-to-POLR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B3GALT1 grouped by POLR1A-low versus POLR1A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1A→partner) and Y-score (partner→POLR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	B3GALT1 →	+0.211	+3.634	<.001	.002	3	2
LARGE_INTESTINE	RAB19 →	+0.932	+3.169	<.001	.006	3	2
LARGE_INTESTINE	GPR3 →	+0.795	+2.502	<.001	.005	3	2
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
LIVER	TAAR6 →	+0.028	+3.459	<.001	.004	3	1
LIVER	CSN3 →	+0.076	+4.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

B3GALT1 by POLR1A expression — BLOOD_Leukemia

Explore this box plot interactively →