POLN

Across TCGA patient cohorts, POLN mutation is significantly associated with the RNA expression of many other genes, with 2,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLN-associated genes across cancer lineages are PBK, TPGS2, and AHRR. Each is linked with POLN in more than 2 cancer types. Because this analysis shows association rather than direction, both POLN-to-partner and partner-to-POLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by POLN-low versus POLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLN→partner) and Y-score (partner→POLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.925	+2.595	<.001	<.001	3	3
COAD	TPGS2 →	+0.463	+3.223	.005	.009	3	3
COAD	AHRR →	+0.660	+3.199	<.001	.009	3	3
UCEC	ERH →	+0.273	+3.743	.009	<.001	3	3
UCEC	DAD1 →	+0.374	+2.354	.002	.003	3	3
UCEC	TXNL4A →	+0.353	+1.917	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,831 associations by consensus.

PBK by POLN expression — UCEC

Explore this box plot interactively →