POLN

Across TCGA pan-cancer cohorts, POLN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of POLN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where POLN RNA is repressed in tumor relative to normal tissue. In most cancer types POLN is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LIHC are the cancer types where POLN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.785	<.001	11	view →
KIRP	Male	All	−0.389	<.001	9	view →
LIHC	All	II,III,IV	+0.629	<.001	7	view →
BRCA	Female	All	−0.276	<.001	6	view →
LUAD	Male	III,IV	+0.313	<.001	5	view →
STAD	All	All	+0.254	.006	4	view →
COAD	All	All	+0.103	<.001	4	view →
PRAD	All	All	+0.385	<.001	2	view →
BLCA	All	All	−0.186	.017	2	view →
CHOL	All	All	+0.195	.045	1	view →
READ	Female	All	+0.172	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

POLN–KICH

Open the KICH breakdown →