POLN

Across TCGA cell cohorts, POLN mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLN-associated genes across cancer lineages are GJD2, MYOG, and OR4X2. Each is linked with POLN in more than 1 cancer types. Because this analysis shows association rather than direction, both POLN-to-partner and partner-to-POLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by POLN-low versus POLN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLN→partner) and Y-score (partner→POLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GJD2 →	+0.013	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	MYOG →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR4X2 →	+0.102	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	SPINT4 →	+0.058	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.006	+4.887	.009	.009	3	1
LARGE_INTESTINE	GHRHR →	+0.037	+2.054	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

GJD2 by POLN expression — BLOOD_Lymphoma

Explore this box plot interactively →