POLM

Across TCGA patient cohorts, POLM mutation is significantly associated with the RNA expression of many other genes, with 653 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLM-associated genes across cancer lineages are MIR3661, RNU105C, and RN7SL248P. Each is linked with POLM in more than 2 cancer types. Because this analysis shows association rather than direction, both POLM-to-partner and partner-to-POLM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by POLM-low versus POLM-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLM→partner) and Y-score (partner→POLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	MIR3661 →	+0.502	+4.661	<.001	.004	3	3
CESC	RNU105C →	+0.233	+5.969	<.001	.002	3	2
UCEC	RN7SL248P →	+0.086	+3.722	<.001	<.001	3	2
CESC	BUB1P1 →	+0.140	+5.010	<.001	.009	3	2
SKCM	MIR525 →	+0.241	+4.743	<.001	.005	3	2
SKCM	MIR596 →	+0.354	+3.993	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 653 associations by consensus.

MIR3661 by POLM expression — KIRP

Explore this box plot interactively →