POLL

Across TCGA patient cohorts, POLL RNA expression is significantly associated with the protein abundance of many other proteins, with 9,983 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLL-associated proteins across cancer lineages are SMC1A, SMC3, and CWF19L1. Each is linked with POLL in more than 5 cancer types. Because this analysis shows association rather than direction, both POLL-to-partner and partner-to-POLL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLL versus SMC1A in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLL→partner) and Y-score (partner→POLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC1A →	+0.248	+0.359	<.001	<.001	3	6
LSCC	SMC3 →	+0.322	+0.450	<.001	<.001	3	6
OV	CWF19L1 →	+0.313	+0.435	<.001	<.001	3	6
OV	P4HB →	-0.496	-0.606	<.001	<.001	3	5
LSCC	HNRNPU →	+0.187	+0.327	<.001	<.001	3	5
LSCC	SART3 →	+0.219	+0.315	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,983 associations by consensus.

POLL vs SMC1A — LSCC

Explore this scatter interactively →