POLL

Across TCGA pan-cancer cohorts, POLL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated POLL data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher POLL RNA is associated with better overall survival. In most high-consensus cancer types, elevated POLL expression acts as an unfavorable survival marker, although some lineages such as UVM and LGG show a favorable association.

UVM, ACC, and LGG are the cancer types where POLL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.769	0.427	<.001	106	view →
ACC	DFS	Tertile	All	0.314	0.750	<.001	61	view →
LGG	OS	Median	All	0.873	0.739	<.001	46	view →
LIHC	DFS	Tertile	All	0.445	0.608	.001	45	view →
BRCA	OS	Median	II,III,IV	0.978	0.938	<.001	44	view →
KIRC	OS	Quartile	All	0.778	0.548	.001	34	view →
SARC	DFS	Tertile	All	0.570	0.355	<.001	30	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	25	view →
COAD	OS	Quartile	II,III,IV	0.780	0.904	.007	22	view →
LUSC	OS	Tertile	II,III,IV	0.593	0.878	.006	19	view →
OV	OS	Median	All	0.275	0.368	.005	16	view →
UCS	OS	Quartile	II,III,IV	0.796	0.408	.046	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

POLL–UVM (OS)

Open the UVM breakdown →