POLL

Across TCGA patient cohorts, POLL mutation is significantly associated with the RNA expression of many other genes, with 1,642 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLL-associated genes across cancer lineages are TRAJ11, GOLGA6L11P, and TMEM269. Each is linked with POLL in more than 2 cancer types. Because this analysis shows association rather than direction, both POLL-to-partner and partner-to-POLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ11 grouped by POLL-low versus POLL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLL→partner) and Y-score (partner→POLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ11 →	+0.468	+2.113	<.001	.002	3	3
UCEC	GOLGA6L11P →	+0.013	+3.292	<.001	.003	3	3
UCEC	TMEM269 →	+0.286	+2.617	<.001	<.001	3	2
HNSC	RN7SL255P →	+0.318	+3.818	<.001	.009	3	2
UCEC	BAG3 →	+0.526	+2.087	.005	.006	3	2
UCEC	MED27 →	+0.370	+3.544	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,642 associations by consensus.

TRAJ11 by POLL expression — UCEC

Explore this box plot interactively →