POLL

Across TCGA patient cohorts, POLL mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLL-associated genes across cancer lineages are 4E-BP1, VHL, and CDK1_pY15. Each is linked with POLL in more than 3 cancer types. Because this analysis shows association rather than direction, both POLL-to-partner and partner-to-POLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by POLL-low versus POLL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLL→partner) and Y-score (partner→POLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.302	+3.199	.010	.009	3	4
UCEC	VHL →	-0.985	-2.115	<.001	.017	3	2
SKCM	CDK1_pY15 →	+0.447	+2.822	.006	.034	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.999	.021	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.182	-3.169	.013	.018	3	1
UCEC	Ku80 →	+0.339	+2.820	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

4E-BP1 by POLL expression — UCEC

Explore this box plot interactively →