POLL

Across TCGA cell cohorts, POLL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,951 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLL-associated GO terms across cancer lineages are Base-excision repair, gap-filling, Viral translational termination-reinitiation, and Sperm motility. Each is linked with POLL in more than 14 cancer types. Because this analysis shows association rather than direction, both POLL-to-partner and partner-to-POLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Base-excision repair, gap-filling grouped by POLL-low versus POLL-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLL→partner) and Y-score (partner→POLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Base-excision repair, gap-filling →	+0.137	+0.764	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.101	+0.830	.001	<.001	3	14
URINARY_TRACT	Sperm motility →	-0.121	-0.818	<.001	<.001	3	12
URINARY_TRACT	Flagellated sperm motility →	-0.121	-0.818	<.001	<.001	3	12
OESOPHAGUS	Cilium-dependent cell motility →	-0.101	-1.056	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.162	-0.989	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,951 associations by consensus.

Base-excision repair, gap-filling by POLL expression — BREAST

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