POLL

Across TCGA cell cohorts, POLL mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLL-associated genes across cancer lineages are PATE4, RNF133, and GSG1L2. Each is linked with POLL in more than 1 cancer types. Because this analysis shows association rather than direction, both POLL-to-partner and partner-to-POLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATE4 grouped by POLL-low versus POLL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLL→partner) and Y-score (partner→POLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PATE4 →	+0.032	+3.510	<.001	.003	3	1
BLOOD_Leukemia	RNF133 →	+0.073	+4.705	<.001	.003	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PATE4 by POLL expression — LARGE_INTESTINE

Explore this box plot interactively →