POLL

Across TCGA cell cohorts, POLL mutation is significantly associated with the mutation status of many other genes, with 3,438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLL-associated genes across cancer lineages are AFAP1, ABHD5, and GLYR1. Each is linked with POLL in more than 2 cancer types. Because this analysis shows association rather than direction, both POLL-to-partner and partner-to-POLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AFAP1 grouped by POLL-low versus POLL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLL→partner) and Y-score (partner→POLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AFAP1 →	+2.459	+3.321	.005	.005	1	3
BLOOD_Leukemia	ABHD5 →	+5.894	+5.321	.002	.002	1	3
LARGE_INTESTINE	GLYR1 →	+1.974	+3.801	.004	.004	1	3
BLOOD_Leukemia	TRIM68 →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	ZNF646 →	+3.020	+4.545	.004	.004	1	2
BLOOD_Leukemia	FAM107A →	+5.894	+5.321	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,438 associations by consensus.

AFAP1 by POLL expression — LARGE_INTESTINE

Explore this box plot interactively →