POLK

Across TCGA patient cohorts, POLK mutation is significantly associated with the RNA expression of many other genes, with 2,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLK-associated genes across cancer lineages are RNA5SP147, OR4M1, and OR4A45P. Each is linked with POLK in more than 2 cancer types. Because this analysis shows association rather than direction, both POLK-to-partner and partner-to-POLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP147 grouped by POLK-low versus POLK-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLK→partner) and Y-score (partner→POLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP147 →	+0.320	+5.324	<.001	.003	3	3
LUSC	OR4M1 →	+0.401	+6.333	<.001	<.001	3	2
BLCA	OR4A45P →	+0.018	+5.051	<.001	.001	3	2
UCEC	C9orf50 →	-0.383	-2.153	.003	.003	3	2
UCEC	RCC1 →	+0.451	+2.785	<.001	<.001	3	2
UCEC	PRF1 →	+0.771	+1.968	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,613 associations by consensus.

RNA5SP147 by POLK expression — BRCA

Explore this box plot interactively →