POLH

Across TCGA cell cohorts, POLH mutation is significantly associated with the RNA expression of many other genes, with 140 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLH-associated genes across cancer lineages are H2BW1, CYLC1, and FAM205C. Each is linked with POLH in more than 1 cancer types. Because this analysis shows association rather than direction, both POLH-to-partner and partner-to-POLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by POLH-low versus POLH-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLH→partner) and Y-score (partner→POLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H2BW1 →	+0.208	+4.977	<.001	.007	3	1
SKIN	CYLC1 →	+0.013	+5.415	<.001	.004	3	1
SKIN	FAM205C →	+0.045	+4.977	<.001	.007	3	1
SKIN	MEIKIN →	+0.022	+5.415	<.001	.004	3	1
SKIN	SMIM36 →	+0.183	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PHF5A →	+0.498	+3.364	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

H2BW1 by POLH expression — SKIN

Explore this box plot interactively →