Across TCGA patient cohorts, POLH-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,527 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLH-AS1-associated proteins across cancer lineages are UHRF1, MCM4, and MCM5. Each is linked with POLH-AS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both POLH-AS1-to-partner and partner-to-POLH-AS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLH-AS1→partner) and Y-score (partner→POLH-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UHRF1 →	+0.486	+0.462	<.001	<.001	3	6
GBM	MCM4 →	+0.658	+0.638	.002	.001	3	6
GBM	MCM5 →	+0.644	+0.651	.003	<.001	3	6
LSCC	MCM2 →	+0.569	+0.525	<.001	<.001	3	6
GBM	SMC2 →	+0.732	+0.655	<.001	<.001	3	6
PDAC	PPP2R5D →	+0.294	+0.322	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,527 associations by consensus.

Exploration

POLH-AS1 survival (RNA) · tumor vs normal (RNA) · all POLH-AS1 data types