Across TCGA pan-cancer cohorts, POLH-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated POLH-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher POLH-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLH-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and THYM show a favorable association.

LIHC, OV, and ACC are the cancer types where POLH-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.710	0.839	<.001	73	view →
OV	OS	Tertile	IV	0.563	0.268	<.001	72	view →
ACC	DFS	Median	All	0.219	0.708	<.001	64	view →
MESO	OS	Quartile	All	0.423	0.652	.002	33	view →
SKCM	OS	Tertile	II,III,IV	0.678	0.792	.006	21	view →
SARC	DFS	Quartile	All	0.202	0.572	<.001	20	view →
THYM	DFS	Quartile	All	0.889	0.610	.008	19	view →
GBM	DFS	Median	All	0.365	0.201	.012	12	view →
UVM	DFS	Median	All	0.290	0.654	.021	12	view →
BLCA	DFS	Quartile	III,IV	0.493	0.356	.036	11	view →
READ	DFS	Median	IV	0.405	0.783	.020	10	view →
ESCA	OS	Median	All	0.629	1.000	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: POLH-AS1 tumor-vs-normal RNA expression · all POLH-AS1 data types