POLG2

Across TCGA patient cohorts, POLG2 mutation is significantly associated with the RNA expression of many other genes, with 2,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLG2-associated genes across cancer lineages are DAGLB, ILK, and CNTROB. Each is linked with POLG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLG2-to-partner and partner-to-POLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAGLB grouped by POLG2-low versus POLG2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG2→partner) and Y-score (partner→POLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DAGLB →	+0.520	+3.415	<.001	.004	3	2
SKCM	ILK →	+0.590	+3.591	.007	.001	3	2
SKCM	CNTROB →	+0.520	+3.591	<.001	.001	3	2
SKCM	CFL1 →	+0.524	+3.604	<.001	.001	3	2
UCEC	TIGD3 →	+0.574	+2.815	.001	.001	3	2
SKCM	RIC8A →	+0.554	+3.616	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,228 associations by consensus.

DAGLB by POLG2 expression — SKCM

Explore this box plot interactively →