POLG

Across TCGA pan-cancer cohorts, POLG Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated POLG data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher POLG Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLG expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, SKCM, and COAD are the cancer types where POLG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	36	view →
SKCM	OS	Median	All	0.389	0.791	<.001	16	view →
COAD	OS	Median	III,IV	0.157	0.791	.001	12	view →
LIHC	DFS	Median	All	0.020	0.554	<.001	12	view →
READ	OS	Median	All	0.281	0.823	<.001	9	view →
UCEC	DFS	Median	All	0.922	0.620	.025	8	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
HNSC	DFS	Median	All	0.209	0.604	.026	6	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

POLG–CESC (DFS)

Open the CESC breakdown →