POLG

Across TCGA pan-cancer cohorts, POLG RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of POLG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLG is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where POLG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.763	<.001	12	view →
KIRC	Male	IV	+0.952	<.001	11	view →
COAD	All	All	+0.521	<.001	10	view →
LIHC	Female	All	+0.792	<.001	8	view →
STAD	Male	II,III,IV	+1.025	<.001	6	view →
CHOL	All	All	+1.888	<.001	5	view →
LUSC	Male	II,III,IV	+0.543	<.001	4	view →
KIRP	Female	All	+0.477	.008	3	view →
THCA	All	II,III,IV	−0.296	.016	3	view →
READ	All	II,III,IV	+1.009	.022	2	view →
UCEC	All	III,IV	+0.599	.040	2	view →
KICH	Female	II,III,IV	+0.548	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

POLG–HNSC

Open the HNSC breakdown →